Osteokare
Osteokare, a key division of Medley Pharmaceuticals, has been a trusted name in the pain and analgesic segment for over a decade. Focused on the management of acute and chronic pain, the division offers a wide portfolio of therapies including NSAIDs, opioids, and adjuvant medications, built on innovation, scientific expertise, and patient-centered care.


Why Pain Management Matters


Pain whether acute or chronic significantly affects comfort, mobility, and overall quality of life. The Osteokare division addresses a broad spectrum of conditions including:

  • ➤ Musculoskeletal pain
  • ➤ Neuropathic pain
  • ➤ Arthritis and fibromyalgia
  • ➤ Post-operative pain
  • ➤ Chronic pain syndromes like diabetic neuropathy

  • With a focus on restoring function and relieving suffering, Osteokare therapies support patients across all age groups.


    Innovation That Leads the Market


    At the heart of Osteokare’s success is its flagship brand:

    Nortipan M

    A market leader in the Nortriptyline + Pregabalin + Methylcobalamin segment, Nortipan M is the first triple combination in India to offer sustained release pregabalin alongside nortriptyline and methylcobalamin. It is a trusted option in the treatment of:

    • ➤ Chronic neuropathic pain
    • ➤ Diabetic neuropathy
    • ➤ Peripheral nerve disorders

    • This unique formulation delivers superior symptom relief, sets a new therapeutic benchmark, and has earned Nortipan M the No. 1 position in its segment.


      All Osteokare products are Patient-Centric, Science-Driven:


      • ➤ Clinically aligned with modern treatment protocols
      • ➤ Developed to maximize therapeutic benefit while minimizing adverse effects
      • ➤ Manufactured in WHO-GMP certified facilities with stringent quality control
      • ➤ Affordable and accessible, helping expand care across urban and rural India

      • Our Commitment

        • ➤ Empowering healthcare professionals with evidence-based, research-driven therapies
        • ➤ Offering customized solutions tailored to each patient’s needs.
        • ➤ Continuing to improve outcomes in the fields of bone health, musculoskeletal disorders, and neuropathic pain

        • Analgesic & Anti-inflammatory

          Acenac Tablet
          Description
          ACENAC Tablets contain Aceclofenac which is a preferential COX 2 inhibitor. Exhibits multiple mechanisms of action. It blocks the prostaglandin (PGE2) secretion and inhibits the release of Cytokines, as well as it stimulates the synthesis of cartilages matrix and blocks its degeneration. Besides this it increases hexosamine level, a gastro protective agent. That's why GI side effects are less associated with this NSAID.
          Indications
          Rheumatoid Arthritis
          Osteoarthritis
          Spondylitis
          Composition
          Each film coated tablet contains :
          Aceclofenac - 100 mg
          Dosage
          100 mg BID
          Side Effects
          • Aceclofenac is well tolerated.
          • GI side effects like dyspepsia, abdominal pain, diarrhoea, and nausea are very rare.
          Precautions
          • As for NSAIDs in general.
          • Aceclofenac should be avoided in patients with moderate to severe renal impairment.
          Presentation
          Acenac is available as a strip of 10 tablets.
          Acenac-SR
          Description
          Cyclooxygenase-2 inhibitors effectively relieve osteoarthritis symptoms when taken in the morning and better results are obtained in rheumatoid arthritis when it is taken in the evening. For achieving longer duration of action and better compliance, drug levels are required to be maintained above effective therapeutic concentration for 24 hours in a day. Sustained release system achieves slow release of drug, which maintains the drug levels in blood or target tissue over an extended period of time. So it provides better efficacy in once daily dose for providing symptomatic relief in Chronic painful conditions like Osteoarthritis, Rheumatoid Arthritis & Spondylitis.
          Indications
          Osteoarthritis
          Rheumatoid Arthritis
          Spondylitis.
          Composition
          Each film coated sustained release tablet contains:
          Aceclofenac Sustained Release - 200 mg
          Dosage administration
          In Osteoarthritis: 1 tablet of Acenac SR in the morning.
          In Rheumatoid Arthritis: 1 tablet of Acenac SR at the night.
          Side Effects
          • Minor like dyspepsia
          • Nausea
          • Heartburn
          Precautions
          • As for NSAIDs in general.
          • Aceclofenac should be avoided in patients with moderate to severe renal impairment.
          Presentation
          Acenac SR is available as a strip of 10 tablets.
          ACENAC-P
          Description
          Pain is a complex phenomena involving both peripheral and central mechanism. The combination of aceclofenac with paracetamol (Acenac-P) gives complete relief from pain and associated inflammation by counter acting both central and peripheral mechanisms. Aceclofenac can counteract peripheral inflammation by blocking COX-2 enzyme and paracetamol block the central effects of prostaglandin by blocking COX-3 enzyme in brain. This combination offers faster and longer duration of action with least incidence of GI side-effects. It works hard on pain, hardly on stomach.
          Indications

          Acute low back pain
          Postoperative pain especially after orthopedic surgeries

          Dental pain
          Dysmenorrhoea

          Sprains and Injuries
           

          Composition
          Each film coated tablet contains
           

          Aceclofenac
          100 mg

          Paracetamol IP
          325 mg

          Dosage
          One tablet twice daily

          Side Effects
          Aceclofenac is well tolerated.
           

          GI side effects like dyspepsia, abdominal pain, diarrhoea, and nausea are very rare.
           

           
           

          Precautions
          As for NSAIDs in general
           

          Aceclofenac should be avoided in patients with moderate to severe renal impairment.
           

           
           

          Presentation
          ACENAC-P is available as a strip of 10 tablets
          Acenac SP tablet
          Composition
          Each tablet of Acenac SP contains:
          Aceclofenac 100 mg
          Paracetamol 325 mg
          Serratiopeptidase 15 mg
          (30,000 Serratiopeptidase units as enteric coated granules)
          Indications
          In pain & swelling associated with:
          Tonsillitis & pharyngitis
          Dental extractions & dental infections
          Post operative swelling
          Sprains and strains
          Presentation
          ACENAC-SP is available as a strip of 10 tablets
          Nortipan tablet
          Composition
          Each tablet of Nortipan contains:
          Nortriptyline 10 mg
          Pregabalin 75 mg
          Indications
          Neuropathic pain
          Diabetic neuropathy
          Surgical neuralgia
          Radiculopathy
          Sciatica
          Low back pain
          Postherpetic neuralgia
          Presentation
          Nortipan is available as a strip of 10 tablets
          Nortipan M tablet
          Composition
          Each tablet of Nortipan contains:
          Nortriptyline 10 mg
          Pregabalin SR 75 mg
          Methylcobalamin 1500 mcg
          Indications
          Diabetic neuropathy
          Sciatica
          Low back pain
          Post-herpetic Neuralgia
          Post-surgical Neuralgia
          Presentation
          Nortipan M is available as a strip of 10 tablets
          NIMSAID – P
          Description
          Nimesulide act peripherally by blocking COX-2 while paracetamol works centrally by blocking COX-3. Both the drugs are well tolerated. The combination of Nimesulide with Paracetamol provides the advantage that the onset of analgesic and antipyretic effect starts faster and the duration of effect is long lasting. Thus combination of the two drugs for rapid and long lasting analgesic and antipyretic action is well justified
          Indications
          Body aches with fever
          Pain
          Composition
          Each uncoated tablet contains:
          Nimesulide
          100mg

          Paracetamol
          325 mg

          Dosage
          One tablet to be taken twice daily
          Side Effects
          Well tolerated
          Contraindication
          Hypersensitivity to any ingredients
          Presentation
          NIMSAID – P is available as a strip of 10 tablets
          Conjoint
          Description
          Conjoint is a combination of natural compounds such as curcumin and piperine. Curcumin exhibits analgesic and anti-inflammatory action. Curcumin targets mechanisms involved in progression of pain and inflammation whereas piperine increases the bioavailability of curcumin. Curcumin also exhibits strong anti-oxidant action and anti-cancer activities.
          Indications
          • Joint pain and discomfort
          • Oral submucous fibrosis
          • Psoriasis
          Composition
          Each capsule contains
          Curcumin (95%)
          500 mg

          Piperine (95%)
          5 mg

          Dosage
          1 capsule once or twice a day
          Presentation
          Strip of 10 capsules
          Conjoint 3D
          Description
          Conjoint 3D contains a combination of ingredients that act together for joint restoration in the management of osteoarthritis. Undenatured collagen type II reduces chondrocyte destruction and increases extracellular matrix of cartilage. Hyaluronic acid improves lubrication of joints and restores elasticity and viscosity of synovia fluid. Nano curcumin and Acetyl Keto Beta Boswellic acid (AKBA) inhibit inflammatory mediators and reduces inflammation and pain.
          Indications
          • Osteoarthritis
          • Inflammatory arthritis
          • Patients awaiting knee replacement surgery
          Composition
          Each softgel capsule contains
          Undenatured Collagen Type II
          40 mg

          Hyaluronic Acid
          40 mg

          Curcuminoids (Nano)
          250 mg

          Piper Nigrum
          5 mg

          Boswellia Serrata Roxb
          30 mg

          Dosage
          One softgel capsule once daily
          Presentation
          Strip of 10 softgel capsules
          Ketotram
          Description
          Ketotram is a combination of Ketorolac and Tramadol which relieve pain. Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) which inhibits prostaglandin synthesis that cause pain and inflammation. Tramadol is an opioid analgesic which works by blocking transmission of pain signals to the brain to lower pain perception.
          Indications
          • Short-term treatment of moderate to severe traumatic pain origin (back pain, fractures, dislocations, sprains, cancer)
          • Postoperative pain after major abdominal surgery
          • Dental pain, Molar Extraction
          • In the treatment of neuropathic pain
          Composition
          Each tablet contains:
          Ketorolac tromethamine
          10 mg

          Tramadol hydrochloride
          25 mg

          Dosage
          1 sublingual tablet every 12 hours, not to exceed 7 days of treatment
          Contraindications
          • In patients with hypersensitivity to tramadol & ketorolac
          • In patients with active peptic ulcer, recent gastrointestinal bleeding
          • In poisoning with alcohol
          • Sleeping pills and psychotropic drugs
          • Patients with moderate or severe renal impairment should be administered under closed medical supervision
          • Pregnancy and lactation
          Side-effects
          Drowsiness and blurred vision.
          Precautions
          Ketotram should be used with caution in patients with kidney and liver disease.
          Presentation
          Strip of 10 tablets