It is the fixed dose combination of amolodipine (calcium channel blocker) and metoprolol (cardioselective beta blocker), both the drugs have two different mechanism and controls all the factors which controls blood pressure i.e. peripheral vascular resistance, stroke volume and heart rate. Advantages of this combination therapy is that, It effectively achieves target Blood Pressure, Lower incidence of individual drug's side-effects, Produces synergistic effects, Increased patient compliance.

Hypertension uncontrolled on monotherapy.
Hypertension with Ischemic Heart Disease.

Each tablet contains:
Metoprolol succinate (Extended release) - 25 mg
Amlodipine - 5 mg

Dosage should be individualized.
The recommended initial dose is one tablet once daily.

Dizziness, headache, nausea, diarrhoea, fatigue, edema, flushing, palpitations and cold extremities.

Patients who are hypersensitive to any component of this product.
Severe bradycardia, heart block greater than first degree, cardiogenic shock, refractory heart failure, sick sinus syndrome.

Betabest AM is available as a strip of 10 tablets.

It is the fixed dose combination of amolodipine (calcium channel blocker) and metoprolol (cardioselective beta blocker), both the drugs have two different mechanism and controls all the factors which controls blood pressure i.e. peripheral vascular resistance, stroke volume and heart rate. Advantages of this combination therapy is that, It effectively achieves target Blood Pressure, Lower incidence of individual drug's side-effects, Produces synergistic effects, Increased patient compliance.

Hypertension uncontrolled on monotherapy.
Hypertension with Ischemic Heart Disease.

Each tablet contains:
Metoprolol succinate (Extended release) - 50 mg
Amlodipine - 5 mg

Dosage should be individualized.
The recommended initial dose is one tablet once daily.

Dizziness, headache, nausea, diarrhoea, fatigue, edema, flushing, palpitations and cold extremities.

Patients who are hypersensitive to any component of this product.
Severe bradycardia, heart block greater than first degree, cardiogenic shock, refractory heart failure, sick sinus syndrome.

Betabest AM is available as a strip of 10 tablets.

Metoprolol is a beta 1 -selective (cardio selective) adrenergic receptor blocking agent, for oral administration, available as extended release tablet. BETABESTT-XL has been formulated to provide a controlled and predictable release of metoprolol for once daily administration.

Hypertension
Angina pectoris
Heart failure
Post MI

Each tablet contains:
Extended release metoprolol succinate - 25 mg

Hypertension: The usual initial dosage is 50 to 100 mg daily in a single dose. The dosage may increase at weekly intervals until optimum blood pressure reduction is achieved.
Angina pectoris: The usual initial dosage is 100 mg daily, given in single dose. The dosage may be gradually increased at weekly intervals until optimum clinical response has been obtained
Heart failure: The recommended starting dose of BETABEST-XL is 25 mg once daily for two weeks in patients with NYHA class II heart failure.

Tiredness, dizziness, depression, headache, Shortness of breath, bradycardia, diarrhea, nausea, dry mouth, constipation, flatulence.

Severe bradycardia, Heart block greater than first degree, Cardiogenic shock Refractory heart failure, Sick sinus syndrome (unless a permanent pacemaker is in place), Hypersensitivity to any component of this product.

Betabest XL is available as a strip of 10 tablets.

Metoprolol is a beta 1 -selective (cardio selective) adrenergic receptor blocking agent, for oral administration, available as extended release tablet. BETABESTT-XL has been formulated to provide a controlled and predictable release of metoprolol for once daily administration.

Hypertension
Angina pectoris
Heart failure
Post MI

Each tablet contains:
Extended release metoprolol succinate - 50 mg

Hypertension: The usual initial dosage is 50 to 100 mg daily in a single dose. The dosage may increase at weekly intervals until optimum blood pressure reduction is achieved.
Angina pectoris: The usual initial dosage is 100 mg daily, given in single dose. The dosage may be gradually increased at weekly intervals until optimum clinical response has been obtained
Heart failure: The recommended starting dose of BETABEST-XL is 25 mg once daily for two weeks in patients with NYHA class II heart failure.

Tiredness, dizziness, depression, headache, Shortness of breath, bradycardia, diarrhea, nausea, dry mouth, constipation, flatulence.

Severe bradycardia, Heart block greater than first degree, Cardiogenic shock Refractory heart failure, Sick sinus syndrome (unless a permanent pacemaker is in place), Hypersensitivity to any component of this product.

Betabest XL is available as a strip of 10 tablets.

The renin-angiotensin-aldosterone system is one of the most important systems in pathogenesis of cardiovascular diseases including hypertenison. Therefore, it is a very successful drug target for the therapy of these diseases. Olmesartan is effective and has excellent tolerability in Diabetic and Non-diabetic Indian Patients. Moreover Olmesartan lowers the rate of coronary atheroma progression.

• For the treatment of mild to moderate hypertension.

One tablet once daily.
Omen may be administered with or without food.
It is important to take the medication at approximately the same time each day to maintain a consistent concentration of the medication in the body.

Contraindication : Patients who are hypersensitive to this drug or to any ingredient in the formulation.
Pregnancy : Olmesartan belongs to USFDA's pregnancy category D. Hence its use should be discontinued during pregnancy.
The use of Olmesartan medoxomil in patients with severe renal impairment is not recommended

Omen is available as a strip of 10 tablets.

The renin-angiotensin-aldosterone system is one of the most important systems in pathogenesis of cardiovascular diseases including hypertenison. Therefore, it is a very successful drug target for the therapy of these diseases. Olmesartan is effective and has excellent tolerability in Diabetic and Non-diabetic Indian Patients. Moreover Olmesartan lowers the rate of coronary atheroma progression.

• For the treatment of mild to moderate hypertension.

One tablet once daily.
Omen may be administered with or without food.
It is important to take the medication at approximately the same time each day to maintain a consistent concentration of the medication in the body.

Contraindication : Patients who are hypersensitive to this drug or to any ingredient in the formulation.
Pregnancy : Olmesartan belongs to USFDA's pregnancy category D. Hence its use should be discontinued during pregnancy.
The use of Olmesartan medoxomil in patients with severe renal impairment is not recommended

Omen is available as a strip of 10 tablets.

Combinational treatments are recommended in an individual whose blood pressure is markedly above the hypertension goal (e.g. more than 20mmHg systolic or 10mmHg diastolic). It is logical to use a combination which works by complementary mode of action. In Omen AM, Olmesartan inhibits Angiotensin II type 1 receptor which results into decrease in blood pressure and amlodipine inhibits entry of calcium in vascular smooth muscle; this causes vasodilation and reduces blood pressure. Moreover side effect like pedal edema associated with amlodipine can be minimized by co administration of olmesartan.

Hypertension
In the management of Stage II Hypertension

One tablet once daily.

Commonly observed adverse reaction is pedal edema, oliguria and hypotension.

Olmesartan belongs to USFDA's pregnancy category D. Hence its use should be discontinued during pregnancy.
The use of Olmesartan medoxomil in patients with severe renal impairment is not recommended.

Omen is available as a strip of 10 tablets.

• In hypertension associated with diabetes

Omen AM 20 is available as a strip of 10 tablets.

Omen CT is a combination of Olmesartan and Chlorthalidone. Chlorthalidone inhibit the reabsorption of sodium and chloride. Thus increase the excretion of water, sodium and chloride from the body leading to fall in cardiac output and blood pressure. Olmesartan is an angiotensin II receptor blocker with excellent tolerability and safety. Olmesartan inhibits the RAAS system hence decreases blood pressure by different mechanism. Thus the combination exerts the additive effect in controlling the blood pressure.

Hypertension uncontrolled with monotherapy

One tablet daily.
Take the medication at approximately the same time each day to maintain a consistent concentration

Hypokalemia, hyperglycemia.

Patients with existing fluid and electrolyte disturbances
Severe hepatic impairment
Renal impairment

Omen CT is available as a strip of 10 tablets.

Being a multi-factorial disease, management of hypertension often requires multiple drugs.Combining antihypertensive agents not only targets the underlying pathways for blood pressure, but also overcomes the side effect of individual drugs by complimentary mechanism of each other.Amlodipine is associated with the activation of the renin–angiotensin system (RAS) and the sympathetic nervous system. Olmesartan can effectively prevent the amlodipine associated activation of RAS.Amlodipine is known to cause peripheral edema, but when given in combination with Olmesartan, the incidence of peripheral edema is reduced. (Amlodipine is the arterio-dilator causes peripheral edema and olmesartan is veno-dilators because of which it causes post-capillary dilatation & reduces peripheral edema). Chlorthalidone can cause hypokalemia & olmesartan causes hyperkalemia thus these two drugs when given together maintain the potassium levels in blood.

Hypertension uncontrolled on dual therapy
Refractory Hypertension

1 tablet to be taken once daily preferably at the same time everyday.

Omen-ACT is available as a strip of 10 tablets.

In patients with mild to moderate hypertension unresponsive to monotherapy with Amlodipine, additional therapy with Atenolol further improves B.P. control. Amlodipine in Primodil-AT reduces B.P. by reducing peripheral resistance. Atenolol in Primodil-AT reduces B.P. by reducing heart rate and force of myocardial contraction; this reduces cardiac output, which in turn reduces blood pressure. The combination of Amlodipine and Atenolol is also very effective in angina because in Primodil-AT, Amlodipine increases oxygen supply to myocardium, while Atenolol decreases oxygen demand.

Hypertension with IHD

In both hypertension and angina, PRIMODIL – AT tablet is given once daily.

Primodil AT is well tolerated. The common side effects are headache, ankle edema, etc.

Hypersensitivity to either of the drugs. Congestive cardiac failure. Pregnancy and lactation.

Primodil AT is available as a strip of 10 tablets.