Ceftriaxone IIIrd generation cephalosporins. Tazobactam the inhibitors of variety of plasma mediated b-lactamases. Ceftriaxone in combination with Tazobactam given in one dose immediately after infection shows a significant reduction in bacterial count.
Lower respiratory tract infections, Nosocomial infections, and surgical prophylaxis
Meningitis, Skin and soft tissue infection like cellulitis. Chronic suppurative bacterial Otitis media, Bone & Joint infections, Sexually transmitted disease (gonorrhea, syphilis), Urinary tract infections (complicated by underlying urological abnormalities).
The usual daily dose is 1-2 gm given once a day. Total daily dose should not exceed 4gms.
Pediatric Patients: Recommended total daily dose (in terms of ceftriaxone) 50 to 75 mg / kg given once in a day (or in equally divided doses twice a day). The total daily dose not to exceed 1gm.
GI effects 2 to 3%, cutaneous reactions 1-3%, hematologicals 1-2% Miscellaneous 1.5 to 3%. Rarely, acute anaphylaxis to any of the drug may occur in susceptible individuals.
Pregnancy: not advisable for the use
Nursing Mother: caution to exercise.
Pediatric Use: Not to be recommended to hyper bilirubinemic neonates, especially premature.
TAZOCEF 0.2812 is available as a strip of 10 tablets