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Suprakare
Suprakare is the 2nd biggest divison of Medley catering mainly to Orthopaedic & Gastroenterology segments. It is also the fastest growing division of Medley & has one of the most innovative and first time launches in the Indian Pharmaceutical Market like DOMPAN (Domperidone plus pantoprazole), Ostium k2 ( 1st brand of Vitamin K27 combination in india), Tazocef (Tazobactam plus Ceftriaxone), Acenac-N (Aceclofenac plus Pregabalin) to name a few. Today, all of them feature amongst the top 5 brands in their respective segments.

Analgesic and Anti-inflammatory

Acenac Tablet
Description
ACENAC Tablets contain Aceclofenac which is a preferential COX 2 inhibitor. Exhibits multiple mechanisms of action. It blocks the prostaglandin (PGE2) secretion and inhibits the release of Cytokines, as well as it stimulates the synthesis of cartilages matrix and blocks its degeneration. Besides this it increases hexosamine level, a gastro protective agent. That's why GI side effects are less associated with this NSAID.
Indications
Rheumatoid Arthritis
Osteoarthritis
Spondylitis
Composition
Each film coated tablet contains :
Aceclofenac - 100 mg
Dosage
100 mg BID
Side Effects
  • Aceclofenac is well tolerated.
  • GI side effects like dyspepsia, abdominal pain, diarrhoea, and nausea are very rare.
Precautions
  • As for NSAIDs in general.
  • Aceclofenac should be avoided in patients with moderate to severe renal impairment.
Presentation
Acenac is available as a strip of 10 tablets.
Acenac-SR
Description
Cyclooxygenase-2 inhibitors effectively relieve osteoarthritis symptoms when taken in the morning and better results are obtained in rheumatoid arthritis when it is taken in the evening. For achieving longer duration of action and better compliance, drug levels are required to be maintained above effective therapeutic concentration for 24 hours in a day. Sustained release system achieves slow release of drug, which maintains the drug levels in blood or target tissue over an extended period of time. So it provides better efficacy in once daily dose for providing symptomatic relief in Chronic painful conditions like Osteoarthritis, Rheumatoid Arthritis & Spondylitis.
Indications
Osteoarthritis
Rheumatoid Arthritis
Spondylitis.
Composition
Each film coated sustained release tablet contains:
Aceclofenac Sustained Release - 200 mg
Dosage administration
In Osteoarthritis: 1 tablet of Acenac SR in the morning.
In Rheumatoid Arthritis: 1 tablet of Acenac SR at the night.
Side Effects
  • Minor like dyspepsia
  • Nausea
  • Heartburn
Precautions
  • As for NSAIDs in general.
  • Aceclofenac should be avoided in patients with moderate to severe renal impairment.
Presentation
Acenac SR is available as a strip of 10 tablets.
Acenac-N
Description
Mixed pain syndrome is associated with conditions like low back pain, sciatica, radiculopathy (cervical & lumbar) & chronic post operative pain. Aceclofenac takes care of nociceptive (inflammatory) pain by inhibiting prostaglandin synthesis. Pregabalin binds to α2-δ subunit of voltage gated calcium channels & reduces the release of neurotransmitters like glutamate and substance P. This reduction in neurotransmitter release accounts for pregabalin's analgesic action. Both component of mixed pain syndrome nociceptive (inflammatory) & neuropathic pain are taken care by aceclofenac & pregabalin respectively.
Indications
Low back pain
Sciatica
Cervical radiculopathy
Lumbar radiculopathy
Post-operative pain following orthopedic surgery
Composition
Each tablet contains :
Aceclofenac Sustained release - 200 mg
Pregabalin Sustained release - 75 mg
Dose
1 tablet once daily or as directed by the physician.
Adverse effects
Dizziness, somnolence, dry mouth, edema, weight gain, abdominal pain.
Contraindications
Hypersensitivity to any of the ingredients.
Presentation
Acenac- N is available as a strip of 10 tablets.