Rabeprazole in DOMRAB is PPI (Proton Pump Inhibitor) which suppresses gastric acid secretion by inhibiting H+ K+ ATPase. It has faster onset of action and faster symptom control than other PPI. It is well tolerated with less potential drug interactions.
Domperidone is prokinetic agent from the class of antidopaminergics. It selectively blocks dopamine receptors (D2) in Stomach & CTZ (Chemo receptor trigger zone) and stops reflux of acidic contents of stomach to esophagus and improves peristalsis pushing gastric content downward. It is developed in sustained release form for longer duration of action with convenience of once daily dose. Rabeprazole provide faster onset of action while domperidone ensure longer duration of action and hence combination of Rabeprazole & Domperidone SR is effective to treat symptoms underlying causes of reflux disease.
Nausea & Vomiting associated with post operative conditions
Domrab is available as a strip of 10 capsules.